You can use any attack style killing Shredder.
Shredder's first mechanic is that he can turn all the food in your inventory into rotten food. This means that there's no real way to use food in the Ninja Turtles Raid.
Shredder's second, and perhaps most important mechanic, is that at half-health he will re-spawn all of the turtles in the raid. When this happens you must stop attacking Shredder! Any damage done before all the turtles are killed again will only serve to heal Shredder. It is recommended that you switch to single-target damage to kill the turtles this time around to avoid healing Shredder with the AoE from your attacks.
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